Description
High quality furazolidone powder // CAS 67-45-8, Furazolidone FDA
USP Standard Top Quality Furazolidone
English name: Furazolidone
Molecular formula: C8H7N5O3
Molecular weight: 225.16
Traits: This product is yellow crystalline powder, odorless, early tasteless, after slightly bitter, in the bright color darker, 255-259 ℃ melting at the same time decomposition. This product is almost insoluble in water, ethanol, very slightly soluble in chloroform, dissolved in dimethylformamide. PH value of 6, the water solubility of 60mg / L, saturated aqueous solution pH value of 4.5-7.0, easily decomposed in the base.
Quality Standard:
A: Compliance with the People’s Republic of China Ministry of Health Drug Standards (1989) edition
Appearance: yellow crystalline powder
Content: 97.0 to 103.0%
Acidity: 5.5 ~ 7.0
Loss on drying: ≤0.5%
Residue on ignition: ≤0.2%
Dissolved in ethanol: ≤0.5%
Heavy metals: ≤20ppm
B: Comply with British Pharmacopoeia (2001)
Appearance: yellow crystalline powder
Content: 97.0 to 103.0%
Acidity: 4.5 ~ 7.0
Loss on drying: ≤0.5%
Sulfuric acid ash: ≤ 0.1%
5-nitro-furfural diethyl ester: ≤ 0.1%
Role and use: anti-bacterial, anti-fungal, antigen biological.
Applications:
Use in humans In humans
Furazolidone is used to treat diarrhoea and enteritis caused by bacteria or protozoan infections. It has been used to treat traveler’s diarrhoea, cholera and bacteremic salmonellosis.
Use in treating Helicobacter pylori infections has also been proposed.
Furazolidone is also used for giardiasis (due to Giardia lamblia), though it is not a first line treatment.
As for all medicines the most recent local recommendations for its use should be always be followed. The usual dose is:
Adult: 100 mg 4 times daily. Usual duration: 2-5 days, up to 7 days in some patients or 10 days for giardiasis.
Child: 1.25 mg/kg 4 times daily, usually given for 2-5 days or up to 10 days for giardiasis.
Use in animals
As a veterinary medicine, furazolidone has been used with some success to treat salmonids for Myxobolus cerebralis infections.
It has also been used in aquaculture.
Use in laboratory
Furazolidone is used to differentiate micrococci and staphylococci.
Storage: Store in cool & dry place not freeze., keep away from strong light and heat
Specification
| Item | Standard | Results |
| Description | Yellow crystal powder | complies |
| Identification | positive | complies |
| Acidity | 5.5-7.0 | 6 |
| Loss on drying | 0.5% max | 0.001 |
| Residue on ignition | 0.1% max | 0.001 |
| Assay | 97-103% | 0.9935 |
| Related compounds | meets the requirements | complies |
| Melting point | 257-259° | 257.5° |
| Nitrofurfural diacetate | 1.0% max | 0.002 |
| Product Name | Furazolidone |
| Synonyms | 2-Furanmethanimine, 5-nitro-N-(2-oxo-3-oxazolidinyl)-;2-Oxazolidinone, 3-((5-nitrofurfurylidene)amino)-;2-Oxazolidinone, 3-((5-nitrofurfurylidine)amino)-;2-Oxazolidinone, 3-[[(5-nitro-2-furanyl)methylene]amino]-;2-Oxazolidinone,3-[[(5-nitro-2-furanyl)methylene]amino]-;3-(((5-nitro-2-furanyl)methylene)amino)-2-oxazolidinon;3-(((5-Nitro-2-furanyl)methylene)amino)-2-oxazolidinone;Furaxon |
| CAS | 67-45-8 |
| MF | C8H7N3O5 |
| MW | 225.16 |
| EINECS | 200-653-3 |
| Product Categories | Active Pharmaceutical Ingredients;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical intermediate;FUROXONE;Pharmaceutical intermediates |
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